Subject(s)
Humans , Animals , Male , Female , Child, Preschool , Child , Tinea/diagnosis , Larva Migrans/diagnosis , Dermatitis, Contact/diagnosis , Scyphozoa , Dermatitis, Contact/etiology , Diagnosis, DifferentialSubject(s)
Humans , Female , Child , Play and Playthings , Borates/adverse effects , Dermatitis, Contact/diagnosis , Dermatitis, Contact/etiologyABSTRACT
Los aceites esenciales (AEs), pertenecientes al geÌnero Lippia, son candidatos interesantes de formulaciones toÌpicas en el tratamiento de la leishmaniasis cutaÌnea (LC). El objetivo de este trabajo fue determinar el perfil toxicoloÌgico y la actividad anti-Leishmania de AEs obtenidos de plantas colombianas del geÌnero Lippia. Ratones BALB/c fueron tratados toÌpica u oralmente con AEs obtenidos de L. alba quimiotipo citral (AE1) y de L. origanoides quimiotipos timol (AE2), carvacrol (AE3) y felandreno (AE4). El efecto del tratamiento en la irritacioÌn de la piel, la toxicidad aguda oral, la genotoxicidad (prueba cometa y micronuÌcleos), los cambios en la funcioÌn hepaÌtica y renal, la induccioÌn de reaccioÌn de hipersensibilidad de contacto y en la actividad contra L. (V) panamensis y L. (V.) braziliensis fueron determinados. Todos los AEs presentaron un perfil toxicoloÌgico similar a los paraÌmetros normales, exceptuando los aceites AE2 y AE3 los cuales fueron irritantes y presentaron algunos signos de toxicidad aguda oral al ser utilizados en altas concentraciones (concentraciones bajas no fueron toÌxicas). El AE2 mostroÌ actividad antiparasitaria en las formas parasitarias evaluadas. Concentraciones bajas de los AEs podriÌan utilizarse de forma segura como componentes de formulaciones farmacoloÌgicas en LC.
Essential oils (EOs) belonging to the genus Lippia are interesting candidates in pharmaceutical systems for cutaneous leishmaniasis (CL). The aim of this work was to determine both toxicological and antileishmanial activities of EOs obtained from different species of Lippia, a widely distributed Colombian plants. BALB/c mice were treated topically or orally with EOs obtained from L. alba citral chemotype (EO1) and L. origanoides thymol (EO2), carvacrol (EO3) and phellandrene (EO4) chemotypes. The skin irritation, oral acute toxicity, genotoxicity (comet assay and micronucleus test), liver and renal adverse effects, All the EOs showed a toxicological profile similar to the normal parameters, except for oils EO2 and EO3 which were irritant and showed some signs of acute oral toxicity at high concentrations (low concentration were safe). The EO2 showed antiparasitic activity. Low concentrations of the EO could be used safely as components of pharmacological formulations in CL.
Subject(s)
Animals , Female , Mice , Oils, Volatile/pharmacology , Leishmaniasis, Cutaneous/drug therapy , Lippia/chemistry , Leishmania/drug effects , Antiprotozoal Agents/pharmacology , Oils, Volatile/adverse effects , Colombia , Comet Assay , Dermatitis, Contact/etiology , Genotoxicity , Mice, Inbred BALB C , Antiprotozoal Agents/adverse effectsABSTRACT
Abstract: Dermatitis caused by bombardier beetles is rarely reported. Here, we report a case of beetle-caused dermatitis that occurred in Pará State, the Brazilian Amazon. A female patient while putting on her shoes, felt a burning pain in the right hallux and noticed a beetle inside the shoe. During medical consultation, the physician observed that the injury site was brown and discolored. The patient complained of localized burning pain and blurred vision. The beetle responsible for the injury was identified as Pheropsophus sp. Administered treatment included cleaning with saline, analgesics, and topical hydrocortisone acetate and the patient was discharged without complaints.
Subject(s)
Humans , Animals , Female , Adult , Coleoptera/classification , Dermatitis, Contact/etiologyABSTRACT
We report the case of a 48-year-old, Caucasian female who presented with slowly progressing asymptomatic poikilodermatous changes of the extensor aspects of the forearms. She also had typical Poikiloderma of Civatte on the V of the neck and erythemato-telangiectatic rosacea of the central face. The patient had been practicing aroma-therapy for many years. Histologic examination revealed findings consistent with PC. Patch-testing revealed positive reactions to Fragrance mix and Nickel sulphate. Based on clinical and histological findings, a diagnosis of extracervical PC was suggested. PC with extra-cervical or extra-facial involvement is rare. In addition, this case supports the theory that contact sensitization to fragrances may contribute to the development of PC.
Subject(s)
Female , Humans , Middle Aged , Aromatherapy/adverse effects , Dermatitis, Contact/pathology , Pigmentation Disorders/pathology , Diagnosis, Differential , Dermatitis, Contact/etiology , Forearm , Neck , Oils, Volatile/adverse effects , Patch Tests , Pigmentation Disorders/etiology , Telangiectasis/pathologyABSTRACT
Venomous animals are those that, by means of a hunting and defense mechanism, are able to inject their prey with a toxic substance produced in their bodies, directly from specialized glands (e.g., tooth, sting, spur) through which the poison passes. Millipedes are poisonous animals; they can be harmful to humans, and their effects usually manifest as erythematous, purpuric, and cyanotic lesions; local pain; and paresthesia. Here, we report a case of skin contact with a millipede for 6h resulting in skin lesions similar to blue toe syndrome.
Subject(s)
Animals , Female , Humans , Young Adult , Arthropods , Blue Toe Syndrome/diagnosis , Dermatitis, Contact/diagnosis , Arthropods/chemistry , Diagnosis, Differential , Dermatitis, Contact/etiology , Time FactorsABSTRACT
La dermatitis por Paederus es un tipo particular de dermatitis de contacto causada por la pederina contenida en la hemolinfa de un pequeño insecto del género Paederus. Se caracteriza por una erupción vesicopustulosa sobre una base eritematosa de rápida aparición, en zonas descubiertas, con el antecedente de exposición al aire libre. El diagnóstico se realiza por las manifestaciones clínicas típicas y el contexto epidemiológico. El objetivo de esta publicación es presentar un caso clínico, y evaluar la epidemiologia y las manifestaciones clínicas de la dermatitis de contacto por Paederus.
Paederus dermatitis is a peculiar contact dermatitis caused by pederine contained in the hemolimph of a small insect of the genus Paederus. It is characterized by vesico-pustulous eruption arising over an erythematous background, of sudden onset, over exposed areas of the body, and the history of outdoor activities. Diagnosis is based on the typical clinical features and the epidemiological context. The aim of this publication is to report a case and evaluate the epidemiological and clinical characteristics of Paederus dermatitis.
Subject(s)
Animals , Child , Humans , Male , Coleoptera , Dermatitis, Contact/etiology , Dermatitis, Contact/diagnosis , Dermatitis, Contact/therapyABSTRACT
A henna é um corante natural, bastante utilizado em tatuagens temporárias, que raramente causa reações alérgicas. Porém, a adição de compostos químicos, como a parafenilenodiamina, pode desencadear reações adversas locais, como dermatite alérgica de contato, hipopigmentação ou hiperpigmentação. A população deve ser orientada quanto aos riscos a curto e a longo prazo desta prática.
Subject(s)
Humans , Dermatitis, Contact/complications , Dermatitis, Contact/etiology , Tattooing/adverse effects , TattooingABSTRACT
As dermatoses causadas por plantas são relativamente comuns no nosso meio e podem ocorrer por diversos mecanismos patogênicos. São descritas dermatoses por trauma físico, por ação farmacológica, mediadas por IgE, por irritação, por ação conjunta da luz e por sensibilização. Também são descritas na introdução desta revisão as pseudofitodermatoses causadas por elementos veiculados pelas plantas e, por isso, aparentemente causadas pelas plantas.
Dermatosis caused by plants is relatively common and may occur by various pathogenic mechanisms. Dermatitis due to physical trauma, pharmacological action, irritation, sensitization, mediated by IgE and induced by light are described. Pseudophytodermatosis caused by plant-delivered elements is also described in the introduction to this work.
Subject(s)
Humans , Dermatitis, Contact/etiology , Plants/adverse effects , Dermatitis, Contact/classificationABSTRACT
Allergic contact dermatitis to cement is a delayed-type hypersensitivity reaction in which cytokines interferon-gamma [IFN-gamma] and vascular endothelial growth factor [VEGF] may be involved in persisting erythema and oedema. VEGF and IFN-gamma levels in serum and skin lesions were measured in 32 Egyptian building workers with chronic allergic contact dermatitis due to occupational exposure to cement and 20 healthy controls. Dermatitis patients had significantly higher levels of serum and lesional skin VEGF and IFN-gamma than controls. A significant positive correlation was found between tissue VEGF and the eczema area and severity index [EASI] score in dermatitis patients [r = 0.86]. VEGF and IFN-gamma may play a role in the pathogenesis of cement allergic contact dermatitis
Subject(s)
Humans , Male , Dermatitis, Contact/etiology , Dermatitis, Allergic Contact , Vascular Endothelial Growth Factor A , Severity of Illness IndexABSTRACT
Apresenta-se caso clínico de dermatite de contato e reação a distância por contato com mercúrio elementar. Paciente apresentou eritema, edema e vesículas após contato dérmico com mercúrio. Lesões evoluíram para placas eritematosas com pequenas áreas enegrecidas sugerindo necrose e vesículas secas. Ocorreram lesões eritematosas a distância no tórax, abdômen e face flexora do cotovelo. Dosagem de Hg na urina 36 horas após início do contato foi de 5,9µg/L, e no sétimo dia 19,6µg/L, indicando absorção através da pele inflamada. Lesões dermatológicas por contato direto por mercúrio metálico elementar devem ser esperadas em casos acidentais.
A clinical case of contact dermatitis following direct skin contact with elemental mercury is presented. Patient had metal mercury in contact with extensive part of his leg and foot skin resulting in erythematous, edematous, and vesicular dermatitis. Lesions evolved to erythematous plaques with small scattered areas of necrosis and drying vesicle lesions. Distant lesions appeared in the right forearm, chest and abdomen. Urinary mercury 36h after contact was 5.9 µg/L, and one week later 19.6 µg/L, indicating dermal absorption. dermal absorption. Dermal effects due to elemental mercury must be expected after direct skin contact.
Subject(s)
Adolescent , Humans , Male , Dermatitis, Contact/etiology , Mercury/adverse effectsABSTRACT
Purpose of the study: Contact dermatitis appears among the most frequent occupational diseases particularly in hospital environment. Objectives of the study are to determine frequency of contact dermatitis in the university hospital of Mahdia, to emphasize the clinical profile of and find the causal allergens. We have carried out a transversal study concerning a representative sample of 225 hospital personals working in the university hospital of Mahdia. The study contained a questionnaire searching the dermatological risk, a clinical examination by a dermatologist for a diagnostic orientation and patch tests with European standard and additional series. Contact Dermatitis prevalence was 19, 1% [13.86 - 24.34]. Irritation was the most frequent [11.1%], followed by eczema [5.8%] and urticaria [2.2%]. The profile of the symptomatic staff is a worker or a nurse, from 30 to 40 years old and exercising in paediatrics or obstetrics services. Substances incriminated were gloves [34.9%], disinfectants and antiseptic [30.2%], medicines [16.3%], cleaners [16.3%] and colophony [4.6%]. Prevenvon is based on the replacement of incriminated products by others less aggressive, on the sensitization of the hospital staff towards the cutaneous risk inherent to their professional activity
Subject(s)
Humans , Dermatitis, Contact/etiology , Occupational Diseases/prevention & control , Occupational Diseases/diagnosisABSTRACT
Se presenta un caso de reacción de contacto por la realización de un tatuaje de henna en un paciente pediátrico y se alerta sobre las posibles complicaciones a corto y largo plazo de este procedimiento. Se trata de una niña de 12 años de edad que presentó una dermatitis de contacto después de haberse realizado un tatuaje temporario de henna. Realizó tratamiento con corticoide tópico con mejoría gradual y posterior aparición de una mácula hipocrómica residual post inflamatoria. El test epicutáneo realizado fue positivo para la parafenilenodiamina. La moda del tatuaje de henna se ha hecho común en la edad pediátrica y muchos casos de dermatitis por contacto por henna han sido descriptos en niños. Este procedimiento produce reacciones locales persistentes, erupciones símil eritema multiforme y secuelas pigmentarias, así como problemas con la futura utilización de las tinturas para el cabello debido a la sensibilización a la parafenilenodiamina. Consideramos que la comunicación de este caso es de importancia para alertar al pediatra y al dermatólogo sobre las posibles complicaciones de este procedimiento.
We present a pediatric case of contact reaction to henna tattoo, alerting of the possible short and long-term complications of this kind of procedure. We describe a 12-year-old girl with a contact dermatitis after applying a temporary henna tattoo. There was gradual improvement with the use of topical corticosteroid and evolution to residual hypochromy. Patch test was positive to paraphenilenodiamine. "Temporary tattomania" with henna is getting to the pediatric population and many cases of henna contact dermatitis have been described in children. They may present as long lasting local reactions, erythema multiform-like lesions and pigmentary sequels apart from problems with the future use of hair dyers as a result of sensitization by paraphenilenodiamine. Thus we believe that the presentation of this case is an opportunity to inform the pediatricians and dermatologists about the possibility of these complications.
Subject(s)
Humans , Female , Child , Dermatitis, Contact/etiology , Lawsonia Plant/adverse effects , Tattooing/adverse effects , Plant Extracts/adverse effects , Lumbosacral RegionABSTRACT
To study the regional variations in the frequency and pattern of dermatoses in amputees in earthquake affected areas. District headquarter hospitals, Mansehra and Abbottabad. All patients with amputations and associated skin disease belonging to any age groups and gender were enrolled for the study. Three visits were made to the research areas. The first visit was for publicizing the time and venue of camps. In the second visit all patients presenting with any major or minor amputation acquired after the earthquake were enrolled in the study. A detailed history was taken and physical examination carried out by a qualified dermatologist. The presence or absence of amputation related dermatoses were specifically recorded and treated. At the third visit all the patients who were managed at the last visit were re-evaluated and assessed in relation to the guidelines provided to them. A total of 210 amputees [159 males and 51 females] volunteered for the study and were enrolled. Their ages ranged from 2 years to 85 years. A total of 210 cases 54 [25.7%] persons had skin lesions including ulcers [n=15], contact dermatitis [10 M, 4 F], adherent scars [6 M, 5 F], abrasions [5 M, 4 F], folliculitis [2 M], inclusion cyst [1 M], hypopigmentation [IF] and hyperpigmentation [IF]. Of the total 54 lesions, 31 lesions were seen in lower and 23 lesions were seen in the upper limb. Ulcers were the most common findings followed by allergic contact dermatitis is another significant problem. Measures should be taken to avoid unnecessary trauma and all patients with dermatitis on the residual limb should be patch tested to determine the cause